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List of drugs and their concentrations used in the drug testing experiments.
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Chemical structures and characterizations of drugs used in this study.
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Screening test with drugs from CiPA list with known interactions and risks performed in three different laboratories ( N = 3–5, n = 6–10). The effects of bepridil, cisapride, <t>disopyramide,</t> ibutilide, and risperidone (red) as well as negative controls DMSO and acetylsalicylic acid (black) were compared to time-matched controls treated only with PBS (grey). ( A ) Kaplan–Meier curve displaying the pacing capability of slices. Statistical analysis by Fisher’s exact test. ( B–H ) Mean and SEM of effects compared to PBS with a two-way ANOVA with Dunnett’s multiple comparison test on the normalized pacing threshold ( B ), normalized force ( C ), FFR ( D ), normalized contraction duration ( E ), CDFR ( F ), normalized ERP ( G ), and changes in diastolic force ( H ). Absolute values of each slice were normalized to values before adding the drug or solvent. Exact n and P values for each condition are given in , .
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https://www.bioz.com/result/disopyramide/product/Millipore
Average 90 stars, based on 1 article reviews
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List of drugs and their concentrations used in the drug testing experiments.

Journal: Frontiers in Physiology

Article Title: CardioMEA: comprehensive data analysis platform for studying cardiac diseases and drug responses

doi: 10.3389/fphys.2024.1472126

Figure Lengend Snippet: List of drugs and their concentrations used in the drug testing experiments.

Article Snippet: Dimethyl sulfoxide (DMSO, Cat. D4540), quinidine (Cat. 22600), nifedipine (N7634), flecainide (Cat. F0120000), amiodarone (Cat. A8423), sotalol (Cat. S0278), and disopyramide (Cat. D2920000) were purchased from Merck KGaA (Darmstadt, Germany).

Techniques: Concentration Assay

Chemical structures and characterizations of drugs used in this study.

Journal: Pharmaceutics

Article Title: The Development and Characterization of Novel Ionic Liquids Based on Mono- and Dicarboxylates with Meglumine for Drug Solubilizers and Skin Permeation Enhancers

doi: 10.3390/pharmaceutics16030322

Figure Lengend Snippet: Chemical structures and characterizations of drugs used in this study.

Article Snippet: TA, Captopril (CPP), and Disopyramide (DPA) were obtained from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan).

Techniques:

Screening test with drugs from CiPA list with known interactions and risks performed in three different laboratories ( N = 3–5, n = 6–10). The effects of bepridil, cisapride, disopyramide, ibutilide, and risperidone (red) as well as negative controls DMSO and acetylsalicylic acid (black) were compared to time-matched controls treated only with PBS (grey). ( A ) Kaplan–Meier curve displaying the pacing capability of slices. Statistical analysis by Fisher’s exact test. ( B–H ) Mean and SEM of effects compared to PBS with a two-way ANOVA with Dunnett’s multiple comparison test on the normalized pacing threshold ( B ), normalized force ( C ), FFR ( D ), normalized contraction duration ( E ), CDFR ( F ), normalized ERP ( G ), and changes in diastolic force ( H ). Absolute values of each slice were normalized to values before adding the drug or solvent. Exact n and P values for each condition are given in , .

Journal: Cardiovascular Research

Article Title: Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs

doi: 10.1093/cvr/cvad141

Figure Lengend Snippet: Screening test with drugs from CiPA list with known interactions and risks performed in three different laboratories ( N = 3–5, n = 6–10). The effects of bepridil, cisapride, disopyramide, ibutilide, and risperidone (red) as well as negative controls DMSO and acetylsalicylic acid (black) were compared to time-matched controls treated only with PBS (grey). ( A ) Kaplan–Meier curve displaying the pacing capability of slices. Statistical analysis by Fisher’s exact test. ( B–H ) Mean and SEM of effects compared to PBS with a two-way ANOVA with Dunnett’s multiple comparison test on the normalized pacing threshold ( B ), normalized force ( C ), FFR ( D ), normalized contraction duration ( E ), CDFR ( F ), normalized ERP ( G ), and changes in diastolic force ( H ). Absolute values of each slice were normalized to values before adding the drug or solvent. Exact n and P values for each condition are given in , .

Article Snippet: Drugs from the CiPA list were added at five different concentration steps into 3–4 mL from the following stocks: bepridil hydrochloride (Tocris Bioscience, UK) 10 mM dissolved in DMSO; ibutilide hemifumarate (Sigma-Aldrich, USA) 10 μM dissolved in H 2 O; disopyramide phosphate (Sigma-Aldrich, USA) 10 mM dissolved in H 2 O; cisapride monohydrate 100 μM dissolved in DMSO; risperidone (Sigma-Aldrich, USA) 1 mM dissolved in DMSO; and acetylsalicylic acid (Sigma-Aldrich, USA) 100 μM dissolved in H 2 O.

Techniques: Comparison, Solvent